Organ Faliure Case Solution And Analysis, HBR Case Study Solution & Analysis of Harvard Case Studies

Organ Faliure Case Study Solution

Comment on the fluid management strategy you will employ. One double space (one reference)

In the patients with lung diseases, the fluid management strategy is required to be cautiously aggressive in nature is known to result in fluid resuscitation that is known to worsen the oxygen level in the human body. This is particularly in the setting where the patient lacks the availability of the ventilation service. But, as the patient is admitted in ICU and is provided with the ventilation facility; the fluid management strategy for the patient is considered to be conservative as she is not found in severe shock that might shorten the time period of ventilation. (WHO, 2020)

On the other hand, the recognition of the shock induced by shock is known to develop the condition of hypotension persisting the challenge of initial fluid management or symptoms of tissue hypo perfusion initiating the resuscitation. In case of septic shock, the patient is required to be given an early and rapid infusion of the intravenous fluids that are crystalloid in the form. Similarly, the use of vasopressor in case of persisting shock despite the liberal resuscitation of fluid.

This is mainly due to the reason that respiratory impairment might occur if the patient is provided with aggressive resuscitation of fluid. But, if no response occurs in the loading of fluid in the patient body and represents the signs of overload volume such as pulmonary edema on chest X-ray, auscultations crackles) then the administration of fluid must be discontinued or reduced.

What other measures should be taken for public safety? One double space (one reference)

The chances of spreading the disease can be significantly reduced by taking following measures:

Regular and thorough cleaning of hands either using soap and water or alcohol-based hand-rub.
Maintenance of at least 3 metre distance between you and the other person. It is important to reduce the probability to transmission of virus through liquid droplets by speaking, sneezing and coughing.
It is important to ensure the good practices regarding the respiratory hygiene by the people around i.e. frequent disposal of used tissues and cleaning of hands.
Self-isolation is recommended even with minor symptoms until you get recovered. This is to avoid the contact of virus containing individuals with the healthy individuals.
In case of cough, fever, difficulty in breathing, an individual is required to consult the general physician by telephone and follow the instructions provided to recover fast.
Be aware of the updated information based on the guidelines and the advices provided by the health practitioners and self-protection.

The consideration of such public safety measures are known to assist not only the infected individual but also the other people to remain safe. This is due to the unpredicted and rapid spread of the disease threatening the life of healthy individuals as well.

Comment on emerging therapies for the treatment of ARDS specifically? Two double spaces (2 reference).

The potential pharmacological therapies for the treatment of ARDS in adults mainly include the following:

Beta agonists:

Despite the dysregulated inflammation, the other hallmark of ARDS mainly includes the accumulation of protein-rich exudative edema fluid in the lung’s airspaces. They are considered effective due to the ability of enhancing the fluid resolution of pulmonary edema and maintenance of endothelial barrier functions.

Systemic steroids:

The use of systemic steroids is known to play a crucial role in the prevention of fully established ARDS. One of the main limitation of using systemic steroids is known to result in adverse effects that might result in the offset of the potential effects of anti-inflammation in patients with ARDS.

Corticosteroids:

High dose of corticosteroids and moderate-dose steroids are known to failure in the efficacy to treat ARDS. Whereas inhaled corticosteroids are known to be used as a safety profile in the early treatment of ARDS. But, the use of inhaled corticosteroid has not been approved because no randomized trials have been performed.

Statins:

The use of statins is considered beneficial for the patients in hospitalization who are likely to develop ARDS. The initiation of Statins in established state of the disease condition to be multifactorial. Additionally, the effect of statins have been confirmed on the pulmonary inflammation in a randomized pre-clinical study demonstrating the wide-ranging effect of simvastatin resulting in anti-inflammation effect during the inhalation model of LPS lipopolysaccharide.

Heparin:

The utilization of inhaled heparin or other related compounds in the inhalation injury due to smoke has been reported. This has significantly resulted in the decreased rate of morbidity and mortality without the increased coagulopathy markers and an increased risk associated with the complication of bleeding. (Festic, 2016)

Aspirin:

In ARDS, the activation of platelets play an important role in the progression of the disease through sequestering within lungs inducing the attraction of inflammatory cells to the damaged tissues of lungs. The use of aspirin for the prevention of ARDS has been has been beneficial followed by decreased neutrophil chemotaxis throughout the pulmonary endothelium.

Stem cell therapy:

The utilization of growth factors or stem cells can help in the repairing of damaged tissues and organs in the human body. The survival of an individual is known to be improved through direct delivery of the stem cells to the bronchial tree and also directly to the lungs. (Andrew James Boyle, 2013)..................................

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